Quarter snapshot

Baker Bros. Advisors

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Quarter: Q4 2025
Filed: 2026-02-17
Portfolio value: $17,078,624,105
Positions: 86
Sources: 13F on EDGAR

Earliest quarter on record — change badges compare to the prior quarter, which isn't stored before this one.

history	Ticker	Change	% of portfolio	Shares	Value
≡	SRZNW	NEW	0.0%	833,333	$16,667
≡	ACRV	NEW	0.0%	22,809	$54,970
≡	TYRA	NEW	0.0%	10,607	$278,858
≡	ALGS	NEW	0.0%	83,055	$774,073
≡	KALA	NEW	0.01%	1,804,055	$1,002,874
≡	SKYE	NEW	0.01%	1,450,638	$1,087,543
≡	SANA	NEW	0.01%	310,483	$1,263,666
≡	TCRX	NEW	0.02%	2,784,792	$2,784,792
≡	VIR	NEW	0.02%	542,539	$3,271,510
≡	FDMT	NEW	0.02%	475,737	$3,568,028
≡	ELVN	NEW	0.02%	271,406	$4,179,652
≡	LBRX	NEW	0.03%	200,000	$4,452,000
≡	TARA	NEW	0.03%	971,614	$5,178,703
≡	SGMT	NEW	0.03%	952,996	$5,641,736
≡	WVE	NEW	0.03%	344,063	$5,849,071
≡	VTVT	NEW	0.03%	148,314	$5,931,077
≡	MPLT	NEW	0.04%	364,705	$6,406,043
≡	RCUS	NEW	0.04%	270,000	$6,434,100
≡	ABSI	NEW	0.04%	2,134,803	$7,450,462
≡	RLAY	NEW	0.06%	1,160,117	$9,814,590
≡	PHVS	NEW	0.06%	375,000	$10,406,250
≡	NUVL	NEW	0.08%	143,937	$14,478,623
≡	ALMS	NEW	0.09%	1,562,500	$15,250,000
≡	DYN	NEW	0.09%	813,449	$15,911,062
≡	SERA	NEW	0.09%	5,498,170	$16,219,602
≡	CTNM	NEW	0.1%	1,420,838	$16,240,178
≡	SION	NEW	0.1%	400,000	$16,456,000
≡	XENE	NEW	0.1%	370,208	$16,592,723
≡	CNTA	NEW	0.1%	670,751	$16,775,483
≡	XNCR	NEW	0.1%	1,102,106	$16,873,243
≡	CLDX	NEW	0.11%	665,370	$18,071,449
≡	CTMX	NEW	0.11%	4,250,826	$18,108,519
≡	TECX	NEW	0.11%	903,400	$18,844,924
≡	NGNE	NEW	0.12%	991,691	$20,428,835
≡	CERS	NEW	0.12%	10,008,345	$20,617,191
≡	DSGN	NEW	0.12%	2,233,099	$20,946,469
≡	ARGX	NEW	0.12%	25,174	$21,170,075
≡	VTYX	NEW	0.12%	2,349,280	$21,213,998
≡	BCRX	NEW	0.13%	2,822,727	$22,017,271
≡	TSHA	NEW	0.13%	4,004,756	$22,026,158
≡	JBIO	NEW	0.15%	1,641,137	$25,322,744
≡	IRON	NEW	0.16%	337,050	$26,765,141
≡	DBVT	NEW	0.16%	1,461,425	$28,015,517
≡	PRLD	NEW	0.17%	10,123,824	$29,359,090
≡	DNTH	NEW	0.19%	789,759	$32,545,968
≡	SYRE	NEW	0.19%	1,000,000	$32,760,000
≡	BNTX	NEW	0.21%	368,923	$35,121,470
≡	TERN	NEW	0.22%	950,000	$38,380,000
≡	RAPP	NEW	0.27%	1,547,090	$46,938,711
≡	TRDA	NEW	0.31%	5,072,730	$52,147,664
≡	VRDN	NEW	0.36%	1,971,678	$61,358,619
≡	DNLI	NEW	0.36%	3,731,695	$61,610,284
≡	RARE	NEW	0.37%	2,772,692	$63,771,916
≡	Unmapped CUSIP	NEW	0.39%	30,750,000	$66,580,023
≡	GLUE	NEW	0.4%	4,345,736	$68,141,140
≡	CRNX	NEW	0.45%	1,648,869	$76,754,852
≡	BCYC	NEW	0.45%	10,885,357	$77,068,328
≡	IMCR	NEW	0.47%	2,322,656	$80,619,390
≡	NRIX	NEW	0.52%	4,658,556	$88,372,807
≡	ABCL	NEW	0.55%	27,525,640	$94,137,689
≡	GPCR	NEW	0.58%	1,432,529	$99,632,392
≡	STOK	NEW	0.62%	3,336,697	$105,906,763
≡	REPL	NEW	0.63%	11,045,336	$107,360,666
≡	KNSA	NEW	0.68%	2,826,246	$116,582,648
≡	ABVX	NEW	0.69%	875,796	$118,105,470
≡	ROIV	NEW	0.71%	5,555,017	$120,543,869
≡	IDYA	NEW	0.73%	3,618,826	$125,102,815
≡	IMTX	NEW	0.74%	12,094,094	$126,987,987
≡	IMVT	NEW	0.81%	5,457,881	$138,739,335
≡	IONS	NEW	0.83%	1,791,841	$141,752,542
≡	ARWR	NEW	0.85%	2,175,645	$144,441,072
≡	EWTX	NEW	0.96%	6,575,940	$163,181,951
≡	GRAL	NEW	1.05%	2,085,333	$178,483,651
≡	ALKS	NEW	1.64%	10,012,267	$280,143,231
≡	PRAX	NEW	1.94%	1,126,488	$332,021,073
≡	KOD	NEW	3.26%	19,919,186	$556,940,441
≡	RYTM	NEW	3.51%	5,604,483	$599,903,860
≡	SMMT	NEW	3.73%	36,391,063	$636,479,692
≡	KYMR	NEW	3.94%	8,657,242	$673,620,000
≡	RVMD	NEW	4.41%	9,455,357	$753,119,185
≡	CELC	NEW	4.62%	7,915,792	$789,521,094
≡	A	NEW	6.71%	42,896,690	$1,145,770,590
≡	INSM	NEW	6.72%	6,592,746	$1,147,401,514
≡	MDGL	NEW	7.3%	2,141,701	$1,247,198,160
≡	ONC	NEW	15.65%	8,799,053	$2,673,240,292
≡	INCY	NEW	17.78%	30,743,991	$3,036,583,991