Baker Bros. Advisors — SYRE

How Baker Bros. Advisors's position in SPYRE THERAPEUTICS INC changed quarter by quarter. Change badges compare each quarter to the fund's immediately-prior filing.

Quarter	Shares	Value	% of portfolio	Change
Q1 2026	1,000,000	$50,440,000	0.29%	—
Q4 2025	1,000,000	$32,760,000	0.19%	NEW